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Microchips Lined by Living Human Cells
What is it?
"With their ability to host and combine the different cell and tissue types making up human organs, organs-on-chips present an ideal microenvironment to mimic human-specific pathophysiologies and enable molecular and cellular scale analysis and identification of new therapeutic targets within an organ-level context in vitro." Wyss Institute
Read more: Around 90% of drugs that have been validated when tested in a petri dish or on animals then failed during clinical trials because of toxicity or lack of effectiveness.
Flower Mound High School student Steven Redding shared a new technique he researched as part of his Capstone Seminar group. Steven's group worked on a project focused on animal testing. This new technique he discussed is basically a human organ on a chip. It could save the lives of countless animals used for medical testing. Tissue and chip technology mimic the mechanical and biochemical behaviors of human organs.
It will change how we test drugs. Researchers and a multidisciplinary team of collaborators are engineering microchips that recapitulate the microarchitecture and functions of living organs, such as the lung, heart, and intestine. These microchips, called organs-on-chips, could one day form an accurate alternative to traditional animal testing. Each individual organ-on-chip is composed of a clear flexible polymer about the size of a computer memory stick that contains hollow microfluidic channels lined by living human cells. Because the microdevices are translucent, they provide a window into the inner workings of human organs. Read Article